The present invention relates to imidazole derivatives of the general formula (I) wherein R1 signifies halogen, lower alkyl or lower alkoxy R2 signifies lower alkyl, lower hydro xyalkyl or lower alkoxyalkyl R3 signifies hydrogen, lower alkyl, lower hydroxyalkyl or alkoxyalkyl Q signifies either -N= or -CH= R4 is a group of formula IIa or lIb (formula IIa and IIb) wherein X, Y and Z independently are -CH= or -N=, and whereby only one of X or Y can be a nitrogen atom R5 and R6 independently are hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, -(CH2)m-(CO)O-lower alkyl, -(CH2)m-S(O)2-lower alkyl, -(CH2)m-C(O)-NRR" and where m = 0-3 and R and R are independently hydrogen or lower alkyl as well as to pharmaceutically acceptable salts thereof. It has now surprisingly been found that the compounds of general formula (I) are metabotropic glutamate receptor antagonists. They can be used in the treatment or prevention of mGluR5 receptor mediated disorders.La presente invención, se refiere a derivados de imidazol de la fórmula general (ver fórmula (I)) en donde R1, significa halógeno, alquilo inferior á alcoxi inferior R2, significa alquilo inferior, hidroxialquilo inferior, o alcoxialquilo inferior R3, significa hidrógeno, alquilo inferior, hidroxialquilo inferior o alcoxialquilo Q, significa ó -N= ó -CH= R4, es un grupo de la formula IIa ó IIb (ver fórmula (IIa y IIb)) en donde, X, Y y Z, son, de una forma independiente, -CH= ó -N= y en donde, solamente una de entre las X ó Y, puede ser un átomo de nitrógeno R5 y R6 son, de una forma independiente, hidrógeno, alquilo inferior, hidroxialquilo inferior, alcoxialquilo inferior, -(CH2)m-(CO)O-alquilo inferior, -(CH2)m-S(O)2-alquilo inferior, (CH2)m-C(O)-NRR, y en donde, m = 0 - 3 y R y R son, de una forma independiente, hidrógeno ó alquilo inferior, así como a las sales farmacéuticamente aceptables de éstos. Se ha encontrado ahora, de una forma sorpre
