Edward Bowman,Maribel Beaumont,Marie-Ange Buyse,Carlo Boutton,Bruno Dombrecht,Robert A. Kastelein,David Vlerick
申请号：
US16415496
公开号：
US20190330340A1
申请日:
2019.05.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
