PUNNONEN, JUHA,BOWMAN, EDWARD,BEAUMONT, MARIBEL,BUYSE, MARIE-ANGE,BOUTTON, CARLO,DOMBRECHT, BRUNO,VICTOR, BJORN,VLERICK, DAVID,KASTELEIN, ROBERT A.
申请号：
CA3003777
公开号：
CA3003777A1
申请日:
2016.11.17
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
