CRAWFORD, Emily D.,CHOW, Eric D.,DERISI, Joseph L.
申请号：
WO2017US46821
公开号：
WO2018035062(A1)
申请日:
2017.08.14
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
A method of sample analysis is provided. In some embodiments, the method comprises: (a) digesting a mixed nucleic acid sample with a plurality of reprogrammed nucleic acid-directed endonucleases that target sequences of interest to produce a digested sample, wherein at least some of the fragments in the digested sample comprise: (i) a sequence of interest and (ii) at least one ligatable end that has been generated by endonuclease cleavage; (b) enriching for fragments that contain the sequence of interest; and (c) analyzing the enriched fragments. Kits for performing the method are also provided.
