RIKKE EVA HUMBLE,TROELS VOLSGAARD CHRISTENSEN,MICHAEL HAROLD ROCK,OLE NIELSEN,HANS PETERSEN,ROBERT DANCER
申请号：
BR0210574
公开号：
BR0210574B1
申请日:
2002.06.25
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof； ii) the precipitate formed is separated from the mother liquor； iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof； iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof； iii) the mother liquor is optionally subjected to further purification and S-citalopram or R-citalopram is isolated from the mother liquor and optionally converted into an addition salt thereof.
