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Charge conversional ternary polyplex
专利权人:
THE UNIVERSITY OF TOKYO
发明人:
Kazunori Kataoka,Yan Lee,Nobuhiro Nishiyama,Kanjiro Miyata,Makoto Oba,Shigehiro Hiki,Mai Sanjo,HyunJin Kim
申请号:
US14543091
公开号:
US09303122B2
申请日:
2014.11.17
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.
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