MANOHARAN, MUTHIAH,MAIER, MARTIN,JAYARAMAN, MUTHUSAMY,MATSUDA, SHIGEO,JAYAPRAKASH, NARAYANANNAIR K.,RAJEEV, KALLANTHOTTATHIL G.,AKINC, AKIN,BAILLIE, THOMAS A.
申请号：
CA2800401
公开号：
CA2800401C
申请日:
2011.06.03
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
