KALINSKI, HAGAR,METT, IGOR,FEINSTEIN, ELENA,ERLICH, SHAI, DR
申请号:
DK08763631
公开号:
DK2170403T3
申请日:
2008.06.26
申请国别(地区):
DK
年份:
2014
代理人:
摘要:
The invention relates to one or more inhibitors, in particular siRNA compounds, which down-regulate the expression of a pro-apoptotic gene selected from the group consisting of TP53; HTRA2; KEAP1; SHC1-SHC, ZNHIT1, LGALS3 and HI95. The invention also relates to a pharmaceutical composition comprising the compound, and a pharmaceutically acceptable carrier. The present invention further provides methods of treating a subject afflicted with a disease or a condition associated with those genes, comprising administering to the subject a pharmaceutical composition in a therapeutically effective dose so as to thereby treat the subject.