TETRAHYDROISOQUINOLINES A SUBSTITUTION ARYLE ET HETEROARYLE ET LEUR UTILISATION POUR BLOQUER LE RECAPTAGE DE LA NOREPINEPHRINE, LA DOPAMINE ET LA SEROTONINE
MOLINO, BRUCE F.,LIU, SHUANG,BERKOWITZ, BARRY A.,GUZZO, PETER R.,BECK, JAMES P.,COHEN, MARLENE
申请号：
CA2573271
公开号：
CA2573271C
申请日:
2005.07.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The compounds of the present invention are represented by the chemicalstructure found inFormula (I):(see formula I)wherein: the carbon atom designated * is in the R or S configuration； and X isa fused bicycliccarbocycle or heterocycle selected from the group consisting of benzofuranyl,benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazoly'l, indolyl,isoindolyl,indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl,imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3a]pyridinyl,thieno[2,3-b]pyridinyl,thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3b]pyridinyl, indenyl, indanyl,dihydrobenzocycloheptenyl,tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl,indolinyl,naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl,quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl,benzo[1,2,4]triazinyl,2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclicheterocycleoptionally substituted with substituents (1 to 4 in number) as defined in R14；with R1, R2, R3, R4,R5, R6, R7, R8, and R14 defined herein.
