Shuang Liu;James P. Beck;Bruce F. Molino;Peter R. Guzzo
发明人:
Bruce F. Molino,Shuang Liu,Peter R. Guzzo,James P. Beck
申请号：
US12252823
公开号：
US08227486B2
申请日:
2008.10.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The compounds of the present invention are represented by the chemical structure found in Formula (I):wherein:the carbon atom designated * is in the R or S configuration； andX is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3 -a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined below in R14； with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.
