MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
SUPER, MICHAEL,DAVIS, JONATHAN H.,STEIN, PASCAL ANDRE
申请号：
CA2635623
公开号：
CA2635623C
申请日:
2006.12.21
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Anti-CD19 B4 antibodies with modified variable regions are disclosed. Themodified anti-CD19 variable region polypeptides have alterations to one ormore framework regions or complementarity determining regions of the heavychain variable region or light chain variable region, thereby to reduce a T-cell response.
