Methods of use of anti-CD19 antibodies with reduced immunogenicity

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专利权人:

Merck Patent GmbH

发明人:

Michael Super,Jonathan Davis,Pascal Andre Stein

申请号：

US14620955

公开号：

US10072092B2

申请日:

2015.02.12

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

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