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含氮飽和雜環化合物
- 专利权人:
- SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.;MITSUBISHI TANABE PHARMA CORPORATION
- 发明人:
- IIJIMA, TORU,饭嶋 彻,飯嶋 徹,SUGAMA, HIROSHI,须釜 宽,須釜 寬,KAWAGUCHI, TAKAYUKI,川口 隆行,HIRAI, MIKI,平井 未希,SHEN, JINGKANG,沈竞康,沈競康,XIA, GUANGXIN,夏广新,夏廣新,XIE, JIANSHU,谢建树,謝建樹,饭嶋 彻,飯嶋 徹,须釜 宽,須釜 寬,川口 隆行,平井 未希
- 申请号：
- TW101109070
- 公开号：
- TWI597273B
- 申请日:
- 2012.03.16
- 申请国别(地区):
- TW
- 年份:
- 2017
- 代理人:
- 摘要：
- This invention provides a nitrogen-containing heterocyclic compound to be used for rennin inhibition medicine. A compound and its pharmaceutically acceptable salt, wherein the compound is represented by formula [I], in which, R1 represents cycloalkyl group or unsubstituted alkyl group； R22 represents: 1) optionally substituted aryl group, 2) optionally substituted tetrahydronaphthyl group, 3) optionally substituted diazanaphthyl group, 4) optionally substituted pyridyl group, 5) optionally substituted pyridazopyridyl group, 6) optionally substituted indolyl group, 7) optionally substituted benzofuranyl group, 8) optionally substituted benzothienyl group, 9) optionally substituted quinolyl group, 10) optionally substituted benzodihydropyranyl, 11) optionally substituted dihydrobenzofuranyl group, 12) optionally substituted indazolyl group, 13) optionally substituted pyrropyridyl group, 14) optionally substituted benzoisoxazolyl group, 15) optionally substituted xanthenyl group, 16) optionally substituted indolinyl group, 17) optionally substituted quinazolinyl group, 18) optionally substituted dihydroquinazolinyl group, 19) optionally substituted furanopyridyl group, 20) optionally substituted dihydrofuranopyridyl group, 21) optionally substituted quinoxalinyl group, 22) optionally substituted dihydrothienopyridyl group, 23) substituted dihydropyranoyridyl group, 24) optionally substituted dihydrobenzothienyl group, 25) optionally substituted dihydrothienopyridyl group, 26) optionally substituted imidazolopyridyl group, R represents a lower cycloalkyl group or binds with the terminal of R22 to form a ring, T represents carbonyl group, Z represents -O-, -NH- or a single bond, R3, R4, R5 and R6 are the same or different, and represent hydrogen atom, optionally substituted carbamoyl group or optionally substituted alkyl group.本發明提供一種含氮飽和雜環化合物，前述含氮飽和雜環化合物可用於腎素抑制藥物中。一種化合物以及其藥理上所允許的鹽，其中，前述化合物由式I表示，式中，R1表示環烷基或非取代的烷基；R22表示：1)可以被取代的芳基、2)可以被取代的四氫萘基、3)可以被取代的二氮雜萘基、4)可以被取代的吡啶基、5)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
