Venu Reddy GURIJALA,Satyanarayan Reddy BOLLU,Jacques LEBLANC,Timothy B. LOWINGER,Dennis MCGILLICUDDY,Mao YIN,Aleksandr V. YURKOVETSKIY
申请号：
US16015623
公开号：
US20180369405A1
申请日:
2018.06.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
