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Substituted naphthyridine and quinoline compounds as MAO inhibitors
专利权人:
ダート・ニューロサイエンス・(ケイマン)・リミテッド;ダート・ニューロサイエンス・(ケイマン)・リミテッド
发明人:
ジリアン・バシンガー,グレイム・フリーストーン,ヴァルシャ・グプタ,アラン・カプラン,チ-チン・マク,ベンジャミン・プラット,ヴィンセント・サントラ,ディパンジャン・セングプタ,リノ・ヴァルデス,チ-チン・マク
申请号:
JP2016500681
公开号:
JP6346658B2
申请日:
2014.03.05
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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