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SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS
专利权人:
DART NEUROSCIENCE (CAYMAN) LTD.
发明人:
Jillian Basinger,Graeme Freestone,Varsha Gupta,Alan Kaplan,Chi-Ching Mak,Benjamin Pratt,Vincent Santora,Dipanjan Sengupta,Lino Valdez
申请号:
US14862874
公开号:
US20160074377A1
申请日:
2015.09.23
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention provides a chemical entity of Formula (I)wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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