Banchereau, Jacques F.,Zurawski, Sandra,Zurawski, Gerard,Klechevsky, Eynav,Oh, Sangkon
申请号：
AU2012261597
公开号：
AU2012261597A1
申请日:
2012.12.07
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2012261597A120130110.pdf#####ABSTRACT The present invention includes isolated anti-Langerin vaccines, methods for making and using an isolated anti-Langerin antibody or binding fragment thereof and one or more antigenic peptides at the carboxy- terminus of the isolated anti-Langerin antibody, wherein when two or more antigenic peptides are present, the peptides are separated by the one or more linker peptides that comprise at least one glycosylation site. The present invention also includes isolated vectors for the expression of the anti-Langerin antigen delivery vectors and their manufactures and use. See Drawing Figure 1.WO 2011/032161 PCT/US2O1O/048800 1/10 czz34*PC MYELOID p~ c CD11c, mDCs .4<；) 4: ... .. . .... Langerhians P DCS . Figure 1 FACS on CHOC stable Longerin Tronsfectants Langerin 2G3 antibodies m~t-Lqrriqerrin 2G2~ hIqU.4 6$-~ 'DiL~icei HAl 14-50w...anfl-Lmgcerin 2G3 do；c nM Langerln 15B10 antibodies 'E~ ~ 70 nh-,i-LnrIn 15BJ10 a w~ ~~~ anti-Li ng or in 15 510 ip 40-' 20 nM Figure 2
