ANTICORPS ANTI-HER3 ET LEURS UTILISATIONS

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专利权人:

YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人:

YARDEN, YOSEF,GABORIT, NADEGE,LINDZEN, MOSHIT

申请号：

CA2959716

公开号：

CA2959716A1

申请日:

2015.09.08

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a KDvalue of 10 nM or lower, wherein the polypeptide inhibits neuregulin (NRG) binding to the human HER3 and NRG-induced cancer cell migration and proliferation. Additionally clones NG83 and NG140 are provided which bind human HER-3 with a KDvalue of 10 nM or lower.

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中国工程科技知识中心

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http://www.ckcest.cn/home/