MOSCHEL ROBERT C.;MOSCHEL, LEGAL REPRESENTATIVE MATTHEW KARL;PEGG ANTHONY E.;JAVANMARD SAHAR;LOKTIONOVA NATALIA;PAULY GARY;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE PENN STATE RESEARCH FOUNDATION
发明人:
MOSCHEL ROBERT C.,MOSCHEL, LEGAL REPRESENTATIVE MATTHEW KARL,PEGG ANTHONY E.,JAVANMARD SAHAR,LOKTIONOVA NATALIA,PAULY GARY
申请号：
US20080597773
公开号：
US8188055(B2)
申请日:
2008.03.12
申请国别(地区):
美国
年份:
2012
代理人:
摘要：
Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X1, X2, R1, and R2 are as described herein. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells and inactivating AGT in a tumor cell. The methods comprise, inter alia, administering a compound or pharmaceutically acceptable salt of formula (I).
