The present invention describes a solid pharmaceutical composition of propofol for parenteral administration. The said solid formulation comprising mixture of propofol, at least one oil component, at least one surfactant and at least one co-surfactant and the said mixture is adsorbed on solid carrier to form a stable solid formulation. The said solid pharmaceutical composition of propofol forms nanoemulsion on reconstitution with carrier solvent. The said solid formulation of propofol forms nanoemulsion on reconstitution with carrier solvent having globule size of 100 nm to 1000 nm. In the said solid pharmaceutical composition of propofol the formation of nanoemulsion on reconstitution avoids energy input unlike other methods for preparation of nanoemulsion.
