LABORATORIOS SALVAT S.A.;SANAGUSTIN AQUILUE Javier;LENDINEZ GRIS Maria Del Carmen;DELGADO GANAN Maria Isabel
发明人:
SANAGUSTIN AQUILUE Javier,LENDINEZ GRIS Maria Del Carmen,DELGADO GANAN Maria Isabel
申请号：
IL27147419
公开号：
IL271474D0
申请日:
2019.12.16
申请国别(地区):
IL
年份:
2020
代理人:
摘要：
It relates to an oil-in-water nanoemulsion composition having a continuous aqueous phase and dispersed oil droplets, wherein the nanoemulsion comprises: (a) clobetasol； (b) one or more oil components； and (c) one or more surfactants； together with one or more pharmaceutically acceptable excipients or carriers wherein: the osmolality of the nanoemulsion is comprised from 100 mOsm/Kg to 500 mOsm/Kg； the droplet average size measured by Dynamic light scattering is comprised from 1 nm to 500 nm； the weight ratio between the oil components and the sum of the oil components and one or more surfactants is comprised from 0.001 to 0.5； the weight ratio between the oil component and clobetasol is comprised from 1:1 to 200:1； and the weight ratio between the surfactant and clobetasol is comprised from 2:1 to 200:1. It also relates to processes for its preparation, its use as a medicament, and in the prophylaxis and/or treatment of inflammatory diseases or conditions.
