PARK, JIN OH,박진오,KIM, YONG GIL,김용길,KWON, JEE WOONG,권지웅,KIM, EUN MI,김은미,LEE, JI EUN,이지은,PARK, SUCK YONG,박석용
申请号：
KR1020100131878
公开号：
KR1020120070354A
申请日:
2010.12.21
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A novel method for preparing olmesartan medoxomil is provided to enhance yield and to enable easy production of a finished product without pulverization.CONSTITUTION: A method for preparing olmesartan mesoxomil comprises: a step of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2-(1-trityl-1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate in a mixture solvent of water and acetic acid to preparing (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2-(1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate(olesartan medoxomil).COPYRIGHT KIPO 2012본 발명은 올메사탄 메독소밀의 새로운 제조방법에 관한 것이다. 본 발명 올메사탄 메독소밀의 제조방법은 제조과정을 거치면서 발생하는 유연물질(불순물)의 양이 적어 수율이 높고, 입자도가 미세하여 분쇄공정 없이 완제품 제조가 용이한 장점이 있다.
