Alexander Richard Liam Cecil;Franck Alexandre Silva;Thomas James Hill;Stephen Joseph Shuttleworth
发明人:
Stephen Joseph Shuttleworth,Alexander Richard Liam Cecil,Thomas James Hill,Franck Alexandre Silva
申请号：
US13388164
公开号：
US20120178737A1
申请日:
2010.08.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N—H, N-(C1-C10 alkyl) or S； each X is independently CH or N； R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O； R2 is (LQ)mY； and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.
