PIECZYKOLAN JERZY SZCZEPAN,JERZY SZCZEPAN PIECZYKOLAN,PAWLAK SEBASTIAN DOMINIK,SEBASTIAN DOMINIK PAWLAK,ŻEREK BARTŁOMIEJ,BARTŁOMIEJ ŻEREK,RÓZGA PIOTR KAMIL,PIOTR KAMIL RÓZGA
申请号：
PL397595
公开号：
PL223487B1
申请日:
2011.12.28
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity, preferably 85% identity and ending with the amino acid hTRAIL281； and at least one domain (b) which is a sequence of a cytolytic effector peptide forming pores in the cell membrane, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
