PIECZYKOLAN, JERZY SZCZEPAN,PAWLAK, SEBASTIAN DOMINIK,ZEREK, BARTLOMIEJ MACIEJ,ROZGA, PIOTR KAMIL
申请号：
PH12014501363
公开号：
PH12014501363A1
申请日:
2014.06.16
申请国别(地区):
PH
年份:
2014
代理人:
摘要：
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70 pcnt sequence identity, preferably 85 pcnt identity and ending with the amino acid hTRAIL281 and at least one domain (b) which is a sequence of a cytolytic effector peptide forming pores in the cell membrane, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a).The fusion protein can be used for the treatment of cancer diseases.
