PIECZYKOLAN, JERZY SZCZEPAN,PAWLAK, SEBASTIAN, DOMINIK,ZEREK, BARTOMIEJ MACIEJ,ROZGA, PIOTR KAMIL
申请号：
HK15102266.6
公开号：
HK1201848A
申请日:
2015.03.05
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity, preferably 85% identity and ending with the amino acid hTRAIL281； and at least one domain (b) which is a sequence of a cytolytic effector peptide forming pores in the cell membrane, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
