The present invention provides a kind of method and its application for preparing volatile oil clathrate compound. The method provided by the invention for preparing volatile oil clathrate compound, patchouli oil and perilla leaf oil are included by homogeneous method using beta-cyclodextrin, thus the inclusion compound prepared can prepare HuoXiangZhengQiShui with what, make its not spirituosity, improve stability, it is nonirritant and in good taste, expand the clinic and market applicable surface of HuoXiangZhengQiShui.本發明提供一種製備揮發油包合物的方法及其應用。本發明提供的製備揮發油包合物的方法，採用β-環糊精通過均質法對廣藿香油與紫蘇葉油進行包合，由此製備的包合物可用於製備藿香正氣水，使其不含酒精，提高穩定性，無刺激性且口感好，擴大了藿香正氣水的臨床和市場適用面。
