Timothy E. WEEDEN,Carol A. NELSON,Bruce M. WENTWORTH,Nicholas P. CLAYTON,Andrew LEGER
申请号：
US16265883
公开号：
US20190388547A1
申请日:
2019.02.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure relates to antisense oligonucleotides (AONs), such as phosphorodiamidate morpholino oligonucleotides (PMOs). The present disclosure further relates to the conjugation of multiple PMOs to cationic cell penetrating peptides (CPPs) to enhance the uptake of PMOs into skeletal and cardiac muscle cells.
