Markus HEMMINGER,Ulla GRAUSCHOPF,Frank BAMBERG,Mayumi BOWEN,Robert MÜLLER,Flora FELSOVALYI,Denny CHRISTENSEN
申请号：
US16651444
公开号：
US20200282130A1
申请日:
2018.09.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method of preparing a prefilled syringe is disclosed that includes obtaining a syringe barrel and a needle adaptor cap assembled on the tip of the syringe barrel, wherein the needle adaptor cap has a rubber element tightly sealing the orifice of the tip of the syringe barrel and the syringe barrel together with the needle adaptor cap assembled on the tip of the syringe barrel is sterilized by a first sterilizing. Filling a drug substance into an interior of the syringe barrel and sealing the interior of the syringe barrel. Packaging the syringe barrel with a rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel. Providing a second external surface sterilizing of the packaged syringe barrel with the rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel.
