PROBLEM TO BE SOLVED: To provide an agent for inhibiting the production of advanced glycation end products.SOLUTION: The present invention provides an agent for inhibiting the production of advanced glycation end products comprising a cimifugin derivative as an active ingredient. The cimifugin derivative has an action to inhibit the production of advanced glycation end products and therefore is suitably used for prevention of and/or treatment of diabetes or diabetic complication, and prevention of and/or treatment of skin aging.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】終末糖化産物生成抑制剤を提供する。【解決手段】シミフギン誘導体を有効成分として含有する終末糖化産物生成抑制剤を提供する。シミフギン誘導体はその終末糖化産物生成抑制作用により、糖尿病もしくは糖尿合併症の予防および/または治療、ならびに皮膚老化の予防および/または改善のために好適に用いられる。【選択図】なし