BHATTACHARYA, Samit Kumar,CAMERON, Kimberly O'Keefe,FERNANDO, Dilinie Prasadhini,KUNG, Daniel Wei-Shung,LONDREGAN, Allyn Timothy,MCCLURE, Kim Francis,SIMILA, Suvi Tuula Marjukka
申请号：
ES11713083
公开号：
ES2557895T3
申请日:
2011.03.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) ** Formula ** in which: R1 is -L1-R1, phenyl or a 5- to 6-membered heteroaryl containing 1 to 4 heteroatoms each independently selected from N, O or S, wherein said phenyl or said 5- to 6-membered heteroaryl is optionally fused to a cycloalkyl (C4-C7), cycloalkenyl (C5-C6), phenyl, saturated or partially unsaturated 5- to 6-membered heterocyclyl containing 1 to 4 heteroatoms each independently selected from N, O or S, or a 5- to 6-membered heteroaryl containing 1 to 4 heteroatoms each independently selected from N, O, or S, wherein said phenyl optionally condensed and said 5 to 6 membered heteroaryl optionally condensed is optionally substituted with 1 to 3 substituents selected from halo, hydroxy, oxo, cyano, (C1-C3) alkyl, halogen substituted (C1-C3) alkyl, alkoxy ( C1-C3), halogen-substituted (C1-C3) alkoxy, (C1-C3) -S (O) n-, c icloalkyl (C3-C6), cycloalkoxy (C3-C6), alkyl- (C0-C3) NRXRY, alkyl- (C0-C3) NRXC (O) RY, and alkyl- (C0-C3) C (O) NRXRY； R1 'is phenyl or a 5- to 6-membered heteroaryl containing 1 to 4 heteroatoms each independently selected from N, O or S, wherein said phenyl or said 5- to 6-membered heteroaryl is optionally fused to a cycloalkyl (C4-C7), cycloalkenyl (C5-C6), phenyl, 5- or 6-membered saturated or partially unsaturated heterocyclyl containing 1 to 4 heteroatoms each independently selected from N, O or S, or a heteroaryl of 5 to 6 members containing 1 to 4 heteroatoms each independently selected from N, O, or S, wherein said optionally condensed phenyl and said optionally condensed 5 to 6 member heteroaryl is optionally substituted with 1 to 3 substituents selected from halo, hydroxy, oxo, cyano, (C1-C3) alkyl, halogen substituted (C1-C3) alkyl, (C1-C3) alkoxy, halogen substituted (C1-C3) alkoxy, (C1-C3) alkyl ) -S (O) n, (C3-C6) cycloalkyl, (C3-C6) cycloalkoxy, alkyl- (C0-C3) NR XRY, alkyl- (C0-C3) NRXC (O) RY, and alkyl- (C0-C3) C (O) NRXRY； L1 is O, S, NH, N (C1-C3 alkyl) or (C1-C3) alkylene； Ra each time it
