Vadim Kraynov,Nick Knudsen,Amha Hewet,Kristine de Dios,Jason Pinkstaff,Lorraine Sullivan
申请号：
US13774349
公开号：
US09567386B2
申请日:
2013.02.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Modified relaxin polypeptides and their uses, including therapeutic uses thereof for the treatment of a fibrotic disorder or heart failure are provided. Exemplary embodiments provide for the use of relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol.
