Vadim Kraynov,Nick Knudsen,Amha Hewet,Kristine De Dios,Jason Pinkstaff,Lorraine Sullivan
申请号：
US16285986
公开号：
US10751391B2
申请日:
2019.02.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.
