The present invention relates to compounds of general formula I wherein R is hydrogen and R 1 is hydroxy or acyloxy, or R is acyl and R 1 is hydroxy or acyloxy, X is sulphur, oxygen or NR 10 , wherein R 10 is hydrogen or (C 1-4 )alkyl； Y is sulphur or oxygen； R 2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry； R4 is hydrogen or (C 1-4 )alkyl； R 5 is hydrogen or (C 1-4 )alkyl； R 3 and R 3 ' are hydrogen, deuterium, or halogen； R 6 , R 7 and R 8 are hydrogen, halogen or deuterium； m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10； with the proviso that n plus p are at least 1. These compounds are useful as pharmaceuticals, particularly as antimicrobials.
