COWART MARLON D.,ZHAO CHEN,SUN MINGHUA,BLACK LAWRENCE A.,ZHENG GUO ZHU,GREGG ROBERT J.,ZHANG GEOFF G. Z.,SHEIKH AHMAD Y.,LOU, XIAOCHUN,HENRY, RODGER F.,BARNES DAVID M.,KOLACZKOWSKI, LAWRENCE,HAIGHT AN
申请号：
UAA200811465
公开号：
UA97639C2
申请日:
2007.02.16
申请国别(地区):
UA
年份:
2012
代理人:
摘要：
Octahydro-pyrrolo[3,4-b]pyrrole derivatives or a pharmaceutically acceptable salt, ester, amide, prodrug, or radiolabeled form thereof, wherein Ris alkyl, C-Ccycloalkyl, or (C-Ccycloalkyl)methyl； R, R, R, R, R, and Reach are independently hydrogen, methyl, or fluororaethyl； R, R, R, and Reach are independently hydrogen, alkyl, fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile, with the proviso that when one or more of R, R, R, and Rare alkyl, then at least one of R, R, R, and Ris fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile； Lis a bond, oxygen, sulfur, carbonyl, alkylene,. alkylcarbonyl, alky-lamino, -C(=N-Oalkyl)-, NR, -C(=O)NR-, or -NRC(=O)-； Ris hydrogen or alkyl； Cyis aryl, cycloalkyl, cycloalkcnyl, hctcroaryl, or heterocycle； Z is a substituent Ror a group represented by &ndash；L-Cy； Ris hydrogen, acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxy-imino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, cycloalkyl, fiuoroalkoxy, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, alkylthio, amino, NHR, NRR, -N(R)C(=O)R, -C(=O)NKR, or N(R)SO(R)； Lis a bond, oxygen, sulfur, carbonyl, alkylene, alkylcarbonyl, alkylamino, -C(=N-Oalkyl), NR, -C(=O)NR-, or -NRC(=O)-； Cyis aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle； R, R, R, R, and Rat each occurrence are independently hydrogen,Calkyl, C-Ccycloalkyl, or a (C-Ccycloalkyl)amine； are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.Раскрыты октагидропирроло[3,4-b]пиррольные производные формулы I и II, пригодные для лечения состояний или расстройств, которые предотвращаются или облегчаются с помощью лигандов рецептора гистамина-3.Раскрыты октагидропирроло[3,4-b]
