The present invention relates to a composition for promoting osteoblast differentiation or cartilage cell differentiation, and more specifically, to a composition for promoting bone (tissue) formation to be used for preventing and treating bone and cartilage damage, containing a Stauntonia hexaphylla leaf extract enabled to be safely used without toxicity and side effects by using natural ingredients. The pharmaceutical composition of the present invention, containing Stauntonia hexaphylla leaf extract as an active ingredient, can be used as a periodontitis or osteoporosis medicine for treating or preventing periodontitis or osteoporosis.
