The invention relates to a method for coating polymer microspheres laden with one or more active substances onto a flexible material without melting, comprising the following steps: a) selecting a porous crosslinked polymer； b) incorporating a liquid lipophilic composition at room temperature and containing at least one active substance into the polymer by heating at a temperature higher by 1 to 5° C. than the glass transition temperature of the polymer in order to obtain laden microspheres； c) placing the laden microspheres on the flexible material； d) heating the flexible material with the laden microspheres at a temperature higher by 1 to 10° C. than the polymer melting temperature； e) cooling the flexible material impregnated with the laden microspheres. The coated flexible material of the invention is laden with one or more active substances having a therapeutic, dermatological cosmetic or olfactory effect and the diffusion is controlled on the basis of the polymers used for making the microspheres and on the nature of the active substances.
