the invention relates to \u043f\u043e\u043b\u0438\u043f\u0435\u043f\u0442\u0438\u0434\u0443 for suppression or treatment of itching, where the polypeptide contains \u043d\u0435\u0446\u0438\u0442\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u043f\u0440\u043e\u0442\u0435\u0430\u0437\u0443 where protease capable of \u0440\u0430\u0441\u0449 \u0435\u043f\u043b\u044f\u0442\u044c protein SNARE in participating in the itchy neirone DRG or \u043f\u0440\u0443\u0440\u0438\u0446\u0435\u043f\u0442\u043e\u0440\u0435 molecule for directed delivery (tm), which is able to communicate with the site contact \u044b\u0432\u0430\u043d\u0438\u044f for participating in an itchy neirone DRG or \u043f\u0440\u0443\u0440\u0438\u0446\u0435\u043f\u0442\u043e\u0440\u0435,where the sequestration occurs in relation to endocytosis for inclusion in the \u044d\u043d\u0434\u043e\u0441\u043e\u043c\u0443 in participating in the itchy neirone DRG or \u043f\u0440\u0443\u0440\u0438\u0446\u0435\u043f\u0442\u043e\u0440\u0435, and where the \u0443\u0447\u0430\u0441\u0442\u0432\u0443 the drop box in the neuron DRG or \u043f\u0440\u0443\u0440\u0438\u0446\u0435\u043f\u0442\u043e\u0440 \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u0435\u0442 the protein SNARE domain and \u0442\u0440\u0430\u043d\u0441\u043b\u043e\u043a\u0430\u0446\u0438\u0438,who can provide \u0442\u0440\u0430\u043d\u0441\u043b\u043e\u043a\u0430\u0446\u0438\u044e protease from \u044d\u043d\u0434\u043e\u0441\u043e\u043c\u044b through \u044d\u043d\u0434\u043e\u0441\u043e\u043c\u0430\u043b\u044c\u043d\u0443\u044e membrane and in the cytosol of participating in the neuron DRG or \u043f\u0440\u0443\u0440\u0438\u0446\u0435\u043f itch the torah provided that the polypeptide is not a molecule \u043a\u043b\u043e\u0441\u0442\u0440\u0438\u0434\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e neurotoxin (\u0433\u043e\u043b\u043e\u0442\u043e\u043a\u0441\u0438\u043d\u0430).Изобретение относится к полипептиду для п
