GETTS, Robert C.,KADUSHIN, James,GEORGE-WEINSTEIN, Mindy,GERHART, Jacquelyn,DYLGJERI, Emanuela,RHODES, Kelly
申请号:
EP14725290
公开号:
EP2976109B1
申请日:
2014.03.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.