UNIVERSITE DE GENEVE;ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
发明人:
申请号：
EP01996400.6
公开号：
EP1351722B2
申请日:
2001.11.19
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Compounds having phosphonic acid groups or a derivative thereof, corresponding to the general formula (I) €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ A-[P(O)(OH) 2 ] p €ƒ€ƒ€ƒ€ƒ€ƒ(I), or a pharmaceutically acceptable derivative thereof, wherein A means a residue of a linear, branched or cyclic, saturated or unsaturated, hydrocarbon residue with n carbon atoms, whereby said residue may be substituted by hydroxyl and/or carboxyl and optionally further interrupted by one or more oxygen and/or sulphur and/or nitrogen atoms, carrying p phosphonic acid groups, wherein n is a number from 4 to 70, and p is 3, 4, 5 or 6, are especially suitable to treat surfaces of Endosseous implants to be applied to a human or animal bone to improve osseointegration.
