An IGF-1 production promoter comprises, as an active ingredient: a Citrus depressa Hayata extract, preferably water and/or organic solvent extract of Citrus depressa Hayata fruit or leaves, a supercritical extract of Citrus depressa Hayata fruit or leaves, or a subcritical extract of Citrus depressa Hayata fruit or leaves, the Citrus depressa Hayata extract containing 0.3 mass% or more of polymethoxyflavonoid in solid basis, for example, a Citrus depressa Hayata extract containing 0.2 mass% or more of nobiletin and/or 0.1 mass% or more of tangeretin in solid basis； or polymethoxyflavonoid, such as nobiletin or tangeretin.以下列作為IGF-1產生促進劑之有效成分：台灣香檬萃取物，較佳為台灣香檬之果實或葉的水及/或有機溶劑萃取物、台灣香檬之果實或葉的超臨界萃取物、或台灣香檬之果實或葉的亞臨界萃取物，以固形物換算含有0.3質量%以上之多甲氧基類黃酮的台灣香檬萃取物，例如以固形物換算包含0.2質量%以上之陳黃皮酮及/或0.1質量%以上之橘皮素的台灣香檬萃取物，或是多甲氧基類黃酮，例如陳黃皮酮、或橘皮素。
