Simon Brack,Sarah Batey,Dragan Grabulovski,Julian Bertschinger,Daniel Schlatter,Jörg Benz,David Banner,Michael Hennig
申请号：
US14119002
公开号：
US09085760B2
申请日:
2012.04.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a polypeptide binding to a chymase (EC 3.4.21.39), wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)A(X2)(X3)(X4)(X5)(X6)LSFHKGEKFQIL(X7)(X8)(X9)(X10) (X11)(X12)G(X13)(X14)WEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X1) is R, N, Q, E, K, H, S, T, C, or D； (X2) is E, T, D, Q, L, P, A, S, C, M, N, E, G, A, V or I； (X3) is R, T, H, N, K, S, C, N or Q； (X4) is S, W, T, C, N, Q, F or Y； (X5) is T, H, L, F, C, S, M, N, Q, R, K, G, A, V, I, P, Y or W； (X6) is D, Q, H, E, S, T, C, N, R or K； (X7) is D, N, R, E, Q, S, T, C, K or D； (X8) is M, W, G, F, A, T, C, S, N, Q, Y, V, L, I or P； (X9) is T, H, S, D, C, N, Q, R, K, E or absent； (X10) is V, T, Q, G, A, L, I, P, S, C, M, N or absent； (X11) is P, A, D, G, K, V, L, I, E, R, M, H or absent； (X12) is N, V, P, I, E, T, S, A, G, L, C, M, Q or D； (X13) is D, E, T, P, G, A, V, L, I, S, C, M, N or Q, and (X14) is W, Y, L, G, A, V, I, P, M, or F； (b) an amino acid sequence which is at least 85% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X1) to (X14).
