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POLYPEPTIDE ET PROCÉDÉ D'IMAGERIE
专利权人:
Kyoto University;ARKRAY, Inc.
发明人:
申请号:
EP13858604.5
公开号:
EP2927239A1
申请日:
2013.11.29
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3);where Xaa1 represents an aspartic acid in which a -Y-X' group binds to an α-amino group, X' includes a chelating site and a radioactive metal nuclide chelated by the chelating site, the chelating site being diethylenetriaminepentaacetic dianhydride (DTPA) or 1,4,7-triazacyclononnane-N,N',N"-triacetic acid (NOTA), and Y represents a linker including a group selected from the group consisting of -CH2-(C6H4)-, -NH-C(=S)-, -NH-(CH2) 5-C(=0)-, and a combination thereof.
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