An isolated antibody, or an antigen binding fragment thereof, that binds to an epitope formed by the hCMV proteins UL130 and UL131A, comprising, (a) heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 49, 50 and 51, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 52, 53, and 54, respectively (b) heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 17, 18, and 19, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 20, 21, and 22, respectively (c) heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 1, 2, and 3, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 4, 5, and 6, respectively (d) heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 33, 34, and 35, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 36, 37, and 38, respectively or (e) heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 113, 114, and 115, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 116, 117, and 118, respectively.