雄性激素受體調節劑之晶型农业专利-农业专业知识服务系统

专利权人:: INC.;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;ARAGON PHARMACEUTICALS, INC.;ARAGON PHARMACEUTICALS

发明人:: SMITH, NICHOLAS D.,史密斯　尼可拉斯Ｄ,HERBERT, MARK R.,贺伯特　马克Ｒ,賀伯特　馬克Ｒ,OUERFELLI, OUATHEK,奥尔福里　澳亚西克,奧爾福里　澳亞西克,DILHAS, ANNA,迪尔哈斯　安娜,迪爾哈斯　安娜,史密斯尼可拉斯D,贺伯特马克R,賀伯特馬克R,奥尔福里澳亚西克,奧爾福里澳亞西克,迪尔哈斯安娜,迪爾哈斯安娜

摘要：: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.本發明闡述非晶型及晶型雄性激素受體調節劑4-[7-(6-氰基-5-三氟甲基吡啶-3-基)-8-側氧基-6-硫酮基-5,7-二氮雜螺[3.4]辛-5-基]-2-氟-N-甲基苯甲醯胺。本發明亦闡述包括該雄性激素受體調節劑且適於投與哺乳動物之醫藥組合物，以及單獨或與其他化合物組合使用該雄性激素受體調節劑治療與雄性激素受體活性相關之疾病或病況之方法。