ROBL, JEFFREY A.,KENNEDY, LAWRENCE J.,WALKER, STEVEN J.,LI, JUN,WANG, HAIXIA,WASHBURN, WILLIAM N.,AHMAD, SALEEM,NGU, KHEHYONG
申请号：
TW101115262
公开号：
TW201247627A
申请日:
2012.04.27
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Novel compounds of Formula I: or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R3, R4, R4a, R5a, R5b, R5c, R5d, R5e, R6a, R6b, and R6c are defined herein, are provided which are TGR5 G protein-coupled receptor modulators. TGR5 G protein-coupled receptor modulators are useful, in treating, preventing, or slowing the progression of diseases requiring TGR5 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the TGR5 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
