Jeffrey A. Robl;Jun Li;Lawrence J. Kennedy;Haixia Wang;Saleem Ahmad;Khehyong Ngu;Steven J. Walker;William N. Washburn
发明人:
Jeffrey A. Robl,Jun Li,Lawrence J. Kennedy,Steven J. Walker,Haixia Wang,William N. Washburn,Saleem Ahmad,Khehyong Ngu
申请号：
US14113593
公开号：
US09062028B2
申请日:
2012.04.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Novel compounds of Formula I:or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R3, R4, R4a, R5a, R5b, R5c, R5d, R5e, R6a, R6b, and R6c are defined herein, are provided which are TGR5 G protein-coupled receptor modulators. TGR5 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring TGR5 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the TGR5 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
