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PROCEDURE FOR CLEANING PEGYLED ERYTHROPOIETIN
专利权人:
F.HOFFMANN-LA ROCHE AG
发明人:
KOEHNLEIN, WOLFGANG,KUHNE, WOLFGANG,FALKENSTEIN, ROBERTO,SCHURIG, HARTMUT
申请号:
DK11754693
公开号:
DK2616101T3
申请日:
2011.09.13
申请国别(地区):
DK
年份:
2014
代理人:
摘要:
Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly(ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange SP Sephacryl™ S 500 HR chromatography material conditioned to a conductivity of 21 mS/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly(ethylene glycol) residue can be obtained in a single step with high purity and yield.
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