University of Washington through its Center for Commercialization
发明人:
David W. Russell,Roli K. Hirata
申请号：
US16441889
公开号：
US20190365876A1
申请日:
2019.06.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (HLA) class II-related gene, which results in deficiency in MHC class II expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in HLA class I/class II deficiency. Also provided are the method of using the cells for transplantation and treating a disease condition.
