Translate Bio MA, Inc.;The General Hospital Corporation d/b/a Massachusetts General Hospital
发明人:
申请号：
EP18204559.1
公开号：
EP3511416A1
申请日:
2013.05.16
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided.
